Epion Tablet (Sedative)

Epion Tablet (Sedative)
This product consists of 3 prominent herbs, Valerian, St. John's Wort and Passion. Human clinical trials show that the plant Valerian has sedative effects, which are mostly related to its volatile oils. Biochemical studies show that Valerenic Acid in this herb inhibits Gamma-Aminobutyric Acid (GABA) catabolism in the synaptic connections in the central nervous system. This leads to high concentrations of GABA in the brain tissue which causes sedative effects.
The antidepressant effects of St. John's Wort are due to its Hyperforin compounds, which inhibit the absorption of norepinephrine, dopamine, glutamate, and GABA. Also, Bioflavonoids and Amentoflavone that are found in this plant, inhibit serotonin receptors, particularly 5- HT (1D) and 5—HT(2C). In addition, it reduces Corticotropin-releasing hormone (CRH) and the release of Interleukin 6.
Furthermore, the anxiolytic and sedative effects of Passion are due to Flavonoids including Apigenin and Chrysin, which bind to GABA receptors A and inhibit the reuptake of GABA neurotransmitters. Finally, GABA concentration increases leading to soothing and anxiolytic effects.
Detailed Specifications
  • Sedative; Anxiolytic and antidepressant
  • Treatment for neurologic sleep disorders
  • Treatment for neurological spasms
30 Coated tablet - 350 mg

  • St. John's Wort (Hypericum perforatum L)
  • Passion Flower (Passiflora incarnate L)
  • Valerian (Valeriana ofhcinalis)

  • Children between 6-12 years old:Take 1-3 tablets a day after consulting with a physician.
  • Adults: 1-2 tablets three times a day (maximum dose is up to 5 tablets a day).
  • In case of insomnia: 1-2 tablets should be taken with liquids one to two hours before sleep.
Valeriana oflicinalis: Human clinical trials show that the herb, Valeriana oflicinalis, has sedative effects, which are mostly related to its volatile oil.
Biochemical studies show that valerenic acid inhibits GABA (gamma—Aminobutyric acid) catabolism in the synaptic connections in the central nervous system. This leads to a high concentration of GABA in the brain tissue which causes sedative effects.
Hypericum perforatum L: The antidepressant effects of this plant are due to its hyperforin compounds, which inhibits the absorption of norepinephrine, dopamine, glutamate and GABA. Also, Biflavonolids and amentoflavone that are found in this plant, inhibits serotonin receptors, particularly 5-HT (1 D) and 5-HT (2C). In addition, it reduces corticotropin-releasing hormone (CRH) and the release of interleukin 6.
Passiflora incarnata L: The anxiolytic and sedative effect of this plant are due to the flavonoids that include apigenin and chrysin, which bind to GABA receptors A and inhibit the reuptake of GABA neurotransmitters. Finally, GABA concentration increases leading to soothing and anxiolytic effects.
  • Children under 14 years old.
  • During pregnancy and breast-feeding.
  • Individuals that have skin sensitivity to sunlight should avoid using this drug. If used, they should be less exposed to UV radiation.
This drug does not have any particular type of adverse effect. Although, a few reports show that there were gastrointestinal problems, allergic reactions, and sedation, in the beginning of this treatment.
  • Should not be used concurrently with anticoagulants such as heparin and warfarin.
  • Concurrent use of this drug with digoxin is not recommended.
  • Concomitant use of this drug with benzodiazepines and barbiturates increases the sedative effects.
  • Concurrent use of this drug with drugs metabolized by cytochrome P450 may decrease the concentration of drugs such as oral contra-ceptives, cyclosporines, anticonvulsants, and carbamazepine.
  • Concomitant use of Epion with serotonergic drugs (nefazodone, paroxetine) and SSRIs may increase effects such as nausea, vomiting and agitation.
  • The use of this drug with theophylline, verapamil, simvastatin, and midazolam, can decrease their pharmacological effects.
  • Consult with a physician if this drug is used simultaneously with drugs consisting of the same mechanism (MAO inhibitors).
  • Concurrent uses of this drug with inhibiting and immunosuppressive drugs (cyclosporine, tacrolimus, and sirolimus), protease inhibitors or non-nucleoside reverse transcriptase inhibitors (NNRTIs) that are used to treat HI\L and cytostatic drugs except monoclonal antibodies, are not recommended.
  • Avoid cutting the tablet in half.
  • This drug can be used at anytime.
  • It is not recommended to use this drug concurrently with alcohol.
  • When working with heavy machinery, there is a chance of sleepiness for individuals that use this drug for the first time.
  • keep away from children.
  • Store in a cool and dry place at 20—25°c.
  • IR GMP

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  • Product Code: SUK024
  • Availability: In Stock
  • 3.10 €

Tags: ANTI-DEPRESSANT & SLEEP DISORDERS TREATMENT TABLET